Nutrition
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Prompted by the continued frequency of mechanical complications associated with central venous catheter placement, a more effective and stable and safer catheter placement device has been proposed. Fifteen critically ill surgical patients who required central venous access for total parenteral nutrition (TPN) and fluid management had a central venous catheter placed using the new syringe technique. Despite an equipment-use learning curve, there was no equipment failure. ⋯ In one dehydrated patient, repeated attempts at percutaneous infraclavicular subclavian access were not successful, but internal jugular vein access was gained. There were no mechanical or infectious complications in the 15 patients. The new syringe provides a stable platform, reducing the fumbling usual when disconnecting the needle from the syringe and thereby avoiding the potential complications of dislodgment or hub contamination of the introducer needle and air embolism.
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The polyamines (PA) spermidine (SD) and spermine and their precursor putrescine (PU) play a leading role in the regulation of protein, RNA and DNA synthesis. We examined the role of PA along with other biomarkers of injury in eight victims of multiple trauma in the early post-traumatic period when they were hypermetabolic and highly catabolic. Intravenous nutritional therapy (TPN) was started 48 to 60h after trauma and continued for 6 days. ⋯ Injury stimulated ribonuclease and catecholamine levels were also enhanced by nutritional therapy, peaking on the first and fourth day of TPN, respectively. This study demonstrated for the first time elevated levels of PA in trauma patients that correlated well with the other known measures of protein metabolic response to injury and changes during nutritional therapy. Extracellular PA levels could be used as markers of both catabolic pathology in trauma and of its response to nutritional therapy.
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Comparative Study
Comparison of effects of long-chain and medium-chain triglyceride emulsions during hepatic regeneration in rats.
We examined the effect of long-chain triglyceride (LCT) and medium-chain triglyceride (MCT) emulsions on hepatic regeneration. After approximately 70% hepatectomy, Sprague-Dawley rats were maintained for 96 hours on total parenteral nutrition (TPN) (250 kcal/kg per day; nonprotein calories-nitrogen 160:1) with LCT or MCT as 30% of nonprotein calories. ⋯ Furthermore, the incorporation of 3H-orotic acid into DNA and RNA of regenerating liver cells in the LCT group was higher than in the MCT group 24 hours after hepatectomy. These observations indicate that essential fatty acids--components of the cell membrane and precursors as functional mediators--are very important to hepatic regeneration.