Nutrition
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We investigated whether a reduced iso-α acid derived from an extract of Humulus lupulus L., META060, had an effect on weight gain, body composition, and metabolism in a high-fat-diet (HFD) fed mouse model. ⋯ META060 has potential therapeutic value for managing obesity and insulin resistance, and further research into the mechanism of action is warranted.
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Essential amino acids, especially l-leucine, initiate the signaling of the mammalian target of rapamycin complex-1 (mTORC1) and protein synthesis in skeletal muscle. Current information on the relation between amino acid transporter mechanisms and mTORC1 signaling is sparse. The objectives of this study were to determine whether an increase in leucine availability upregulates the gene transcription and translation of amino acid transporters and other amino acid members in an mTORC1-dependent pathway that control amino acid use (general control non-repressed-2 and activating transcription factor-4) and to measure the factors related to protein synthesis and proteolysis. ⋯ Our findings indicate that the mTOR is a component of the nutrient signaling pathway, which regulates system A and L amino acid transporters, the initiation factors involved in mRNA translation, and is downstream of forkhead box-O in L6 myotubes.
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Fetal malnutrition is an early-life inducer of dyslipidemia and glucose intolerance. The aim of this study was to examine whether maternal azuki bean (Vigna angularis) polyphenol (AP) intake during lactation affects the adenosine monophosphate-activated protein kinase (AMPK) pathway and lipid metabolism in offspring exposed to fetal malnutrition. ⋯ Our results suggest that maternal AP intake during lactation upregulates AMPK phosphorylation not only in young but also in adult offspring exposed to fetal malnutrition and may lead to decreased hepatic lipid accumulation by ACC phosphorylation and downregulation of SREBP-1c expression.
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The identification of the active phenolic compounds in the mixed extract of sea cucumber (Holothuria atra) body wall by high-performance liquid chromatography and an assessment of its hepatoprotective activity against thioacetamide-induced liver fibrosis in rats. ⋯ Sea cucumber mixed extract contains physiologically active phenolic compounds with antioxidant activity, which afforded a potential hepatoprotective activity against thioacetamide-induced liver injury in a rat model.
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Resistant sugars, which have several desirable properties, are often used in food production and the pharmaceutical industry. We evaluated the effects of mannitol on the absorption and retention of calcium (Ca) and magnesium (Mg) in growing rats. ⋯ Absorption and retention of Ca and Mg are promoted by mannitol feeding through the fermentation of mannitol in the cecum.