Nutrition
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In hospitalized patients, the optimal target blood glucose concentration is controversial. Numerous studies have examined clinical use of glucose control in various patient populations. In the present review, we briefly discuss corresponding meta-analyses. ⋯ Eight meta-analyses showed that, despite the intensity of glucose control, the frequency of hypoglycemic episodes increased. The residual heterogeneity of individual studies incorporated into the various meta-analyses prevents a valid conclusion regarding potential benefits of a specific glucose target. A glucose concentration <200 mg/dL appears preferable.
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Randomized Controlled Trial Comparative Study
Differential dose effect of fish oil on inflammation and adipose tissue gene expression in chronic kidney disease patients.
The beneficial effects of ω-3 polyunsaturated fatty acids (PUFAs) in cardiovascular disease are partly attributed to their anti-inflammatory properties. Their potential effect on the adipose tissue of chronic kidney disease (CKD) patients has never been explored. ⋯ A moderate dose of FO alters the gene expression profile of adipose tissue to a more antiinflammatory status. Higher doses of FO have a favorable effect on lipid profile and lead to the upregulation of adipokines gene expression suggesting a different dose response to ω-3 PUFA administration in patients with CKD.
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Albumin plasma concentrations are being used as indicators of nutritional status and hepatic function based on the assumption that plasma levels reflect the rate of albumin synthesis. However, it has been shown that albumin levels are not reliable markers of albumin synthesis under a variety of clinical conditions including inflammation, malnutrition, diabetes mellitus, liver disease, and surgical tissue trauma. To date, only a few studies have measured albumin synthesis in surgical and critically ill patients. ⋯ The results indicate that the fractional synthesis rate of albumin appears to decrease during surgery, followed by an increase during the postoperative phase. In the early postoperative phase, albumin fractional synthesis rate can be stimulated by perioperative nutrition, if enough amino acids are being provided and if nutrition is being initiated before the operation. The physiologic meaning of albumin synthesis after surgery, however, still needs to be further clarified.
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Maternal intake is crucial to pregnancy outcomes. Evidence shows that both nutrient deficiency and excess can have adverse effects. In pregnancy, changes in iron metabolism occur; therefore, dietary reference intakes increase to support expansion of red cells and maternal-fetal transfer of iron. Appropriate and valid assessment tools are required to investigate nutritional concerns in mothers with and without gestational diabetes mellitus (GDM). The objective of this study was to assess the Willett food frequency questionnaire (FFQ) to assess iron intake in women with (n = 15) and without (n = 45) GDM. ⋯ These findings suggest the Willett FFQ is a good tool for assessing total iron intake of French-Canadian pregnant women.
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Randomized Controlled Trial
Glomerular filtration rate after a 12-wk resistance exercise program with post-exercise protein ingestion in community dwelling elderly.
Increased protein intake and resistance exercise can be beneficial for maintenance of lean body mass (LBM) in older adults. However, these factors could also negatively affect renal function. We investigated changes in renal function after a 12-wk resistance exercise program combined with protein supplementation in community dwelling older adults. ⋯ A 12-wk resistance exercise program combined with protein supplementation in community dwelling older adults does not negatively affect GFR. The supplementation had only minor effects on total dietary intake.