Nutrition
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Historical Article
An error in concept and definition of recommended dietary allowance developed in 1941: Time to create new ones.
The recommended dietary allowance (RDA) for vitamin C differs greatly (40-110 mg/d) across countries. In addition, vitamin D deficiency is, effectively, a pandemic, with a prevalence of approximately 25% to 80% across countries according to the findings in the recent scientific literature. ⋯ This is an extremely high intake level for a specific nutrient affecting only a few individuals (the upper 2.5%) of the generally healthy population. The RDA should be redefined by investigating at which intake level of a specific nutrient the incidence of a specific disease or mortality increases or decreases based on prospective cohort studies.
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Gut microbiota dysbiosis is among the risk factors for breast cancer development, together with genetic background and dietary habits. However, caloric restriction has been shown to remodel the gut microbiota and slow tumor growth. Here, we investigated whether the gut microbiota mediates the preventive effects of long-term chronic or intermittent caloric restriction on breast cancer predisposition. ⋯ Our study revealed the role of gut microbes in the preventive effects of caloric restriction against breast cancer development, implying the significance of diet and microbiome interplay.
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To evaluate the association between consumed non-nutritive sweeteners (NNS) and gestational diabetes mellitus (GDM) in a cohort of pregnant women from Santiago, Chile. ⋯ The consumption of NNS, particularly sucralose, is associated with an increased risk of GDM in pregnant women. Further studies are essential to validate these results in other contexts and to guide future recommendations for healthier dietary practices among pregnant populations.