Nutrition
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Some results from cohort investigations indicate that supplemental antioxidants cannot decrease the risks for some diseases and even can play an inverse role because the antioxidant may not be involved in metabolism or may be a pro-oxidant in vivo. Therefore, further studies are required to identify conditions of an antioxidant converting into a pro-oxidant and the pathway of an antioxidant being a metabolic component. Additionally, long-term investigations on large-scale cohorts are required in order to clarify which disease is suitable for antioxidant therapy and how antioxidant intake can really maintain health.
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Rodents have been the most frequently flown animal model used to study physiological responses to the space environment. In support of future of space exploration, the National Aeronautics and Space Administration (NASA) envisions an animal research program focused on rodents. Therefore, the development of a rodent diet that is suitable for the spaceflight environment including long duration spaceflight is a high priority. ⋯ Depending on future animal habitat hardware and planned spaceflight experiments, modification of the NuRFB or development of a new diet formulation may be needed, particularly for long term spaceflights. Research in this area consists primarily of internal technical reports that are not readily accessible. Therefore, the aims of this contribution are to provide a brief history of the development of rodent spaceflight diets, to review the present diet used in rodent spaceflight studies, and to discuss some of the challenges and potential solutions for diets to be used in future long-term rodent spaceflight studies.