Reproductive toxicology
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Reproductive toxicology · Jun 2019
Meta AnalysisUse of ondansetron during pregnancy and the risk of major congenital malformations: A systematic review and meta-analysis.
To investigate whether ondansetron use during pregnancy is associated with increased rates of major or subgroups of malformations. ⋯ Ondansetron use during pregnancy was not associated with a significant increase in rate of major or selected subgroups of malformations in our primary analysis. However, results of the secondary analyses warrant the need for continued surveillance. These results may be reassuring for pregnant women in whom ondansetron use is clinically indicated since the absolute risks of possible concerns appear to be low.