European journal of clinical nutrition
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Randomized Controlled Trial Comparative Study Clinical Trial
Postprandial lipid and hormone responses to meals of varying fat contents: modulatory role of lipoprotein lipase?
Substrate and hormone responses to meals of differing fat content were evaluated in normal subjects in order to investigate mechanisms underlying the regulation of postprandial lipoprotein concentration. ⋯ The results suggest that glucose-dependent insulinotrophic polypeptide may mediate increased lipoprotein lipase activity in response to fat-containing meals and may play a role in circulating lipoprotein homeostasis. This mechanism may be overloaded with high fat meals with adverse consequences on circulating triacylglycerol and NEFA concentrations.