Journal of neurotrauma
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The authors review acute and delayed traumatic intracerebral hemorrhages. Based on recent experimental and clinical data, these injuries' clinical presentation, pathologic characteristics, and treatment are discussed. A description of traumatic hemorrhage based on biomechanics is emphasized.
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Journal of neurotrauma · Mar 1992
Cerebral cardiovascular and respiratory variables after an experimental brain missile wound.
Brain missile wounding (BMW) affects brainstem and medullary cadiorespiratory functions leading to immediate systemic hypertension, bradycardia, and apnea. Secondary complications may also occur because of subsequent changes in systemic and intracranial physiological variables. To delineate the immediate and secondary effects of BMW, we monitored changes in several cerebral and cardiorespiratory parameters in pentobarbital-anesthetized spontaneously breathing cats before wounding and up to 90 min afterward. ⋯ Others had one or several postwounding secondary complications: abruptly increased ICP producing a negative CPP, extreme reductions in CO or CBF and ventilation. Cardiac arrest occurred once. Thus, post-BMW mortality cannot be consistently ascribed to the impairment of a single physiological variable.
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Spinal cord injury models continue to be used to learn more about the pathophysiology of injury as well as potential therapeutic interventions. Most researchers now rely on rat models of injury with injury produced by impact, compression, or even photochemical techniques. A number of laboratories have confirmed that reproducible and graded injury can be produced in the rat with outcome monitored by behavioral, neurophysiologic, and morphologic analyses. ⋯ In addition, a new approach to therapy is being explored via implantation of cells into the injured spinal cord. Cell suspensions can be implanted in clinically relevant injury models without exacerbating the effects of injury and with some indications of beneficial effect. The potential usefulness of such an approach is just beginning to be evaluated.