Journal of clinical anesthesia
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Randomized Controlled Trial Comparative Study Clinical Trial
Ketorolac or fentanyl to supplement local anesthesia?
To evaluate the usefulness of ketorolac in the treatment of intraoperative pain refractory to the administration of local anesthetic alone. ⋯ Ketorolac is a useful alternative to fentanyl for the treatment of intraoperative pain refractory to the administration of local anesthetic alone during monitored anesthesia care. A decided advantage of ketorolac over fentanyl is the absence of nausea and vomiting in the intraoperative and postoperative periods.
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To investigate whether hyperventilation significantly altered oxygen consumption in anesthetized and paralyzed patients undergoing surgery. ⋯ In anesthetized paralyzed patients, there is an increase in whole-body VO2 with hypocapnic alkalosis.
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Randomized Controlled Trial Comparative Study Clinical Trial
Comparison of the efficacy of esmolol and alfentanil to attenuate the hemodynamic responses to emergence and extubation.
To define the ability of esmolol and alfentanil to control the hemodynamic changes associated with extubation and emergence. ⋯ Emergence and extubation after inhalation general anesthesia result in significant increases in BP and HR in healthy patients. An esmolol bolus dose and subsequent infusion significantly attenuated these responses. A small bolus dose of alfentanil minimized the responses to emergence but prolonged the time to extubation and was no longer protective at that point.
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Randomized Controlled Trial Comparative Study Clinical Trial
Pharmacodynamic effects of three doses of ORG 9426 used for endotracheal intubation in humans.
To determine the pharmacodynamic characteristics of three incremental doses of ORG 9426 used for endotracheal intubation in patients. ⋯ These findings warrant further clinical evaluation of ORG 9426 for induction and maintenance of muscle relaxation in humans.
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Randomized Controlled Trial Comparative Study Clinical Trial
Patient-controlled drug administration during local anesthesia: a comparison of midazolam, propofol, and alfentanil.
To evaluate the perioperative effects of alfentanil, midazolam, and propofol when administered using a patient-controlled analgesia (PCA) device during local anesthesia. ⋯ When self-administered as adjuvants during local anesthesia using a PCA delivery system, alfentanil, midazolam, and propofol were equally acceptable to patients. However, propofol and midazolam were associated with fewer perioperative complications than was alfentanil.