Journal of clinical anesthesia
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Randomized Controlled Trial Multicenter Study Clinical Trial
A double-blind, parallel-group, placebo-controlled, dose-ranging, multicenter study of intravenous granisetron in the treatment of postoperative nausea and vomiting in patients undergoing surgery with general anesthesia.
To compare the effectiveness of granisetron with placebo in the treatment of established postoperative nausea and vomiting (PONV). ⋯ Granisetron was significantly more effective than placebo in all groups. Further studies in specific subgroups may be warranted.
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Randomized Controlled Trial Clinical Trial
Spontaneous movements associated with rocuronium injection: the effects of prior administration of fentanyl.
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Randomized Controlled Trial Clinical Trial
Combined popliteal and posterior cutaneous nerve of the thigh blocks for short saphenous vein stripping in outpatients: an alternative to spinal anesthesia.
To compare a combination of peripheral nerve blocks with spinal anesthesia in ambulatory patients undergoing short saphenous vein stripping. ⋯ The combination of popliteal and posterior cutaneous nerve of the thigh blocks provided adequate anesthesia and a faster recovery profile with a similar subjective acceptance of both anesthetic techniques in ambulatory patients undergoing short saphenous vein stripping in the prone position.
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Randomized Controlled Trial Clinical Trial
Ondansetron dose response curve in high-risk pediatric patients.
To establish a dose-response relationship for ondansetron, and to evaluate any effects of oral premedication with metoclopramide in pediatric patients undergoing tonsillectomy and adenoidectomy and strabismus surgery. ⋯ Ondansetron is an effective medication for the treatment and prevention of postoperative nausea and vomiting, and a dose of ondansetron 0.05 mg/kg is as effective as 0.1 mg/kg and 0.15 mg/kg. Metoclopramide 0.15 mg/kg has no effect on the incidence of postoperative nausea and vomiting.
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Randomized Controlled Trial Comparative Study Clinical Trial
Epidural block for obstetrics: comparison of bolus injection of local anesthetic with gravity flow technique.
To test the hypothesis that slow administration of local anesthetic into the epidural space by gravity flow reduces the incidence of signs and symptoms of unintended injection. ⋯ Gravity flow administration of local anesthetic-opioid solution during epidural block for obstetrics was associated with fewer signs of systemic drug absorption and cardiovascular perturbations than was the traditional bolus injection. This study supports the current opinion that slow administration of local anesthetic during epidural block contributes to fewer adverse events.