Journal of clinical anesthesia
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Randomized Controlled Trial Clinical Trial
Evaluation of the efficacy of a forced-air warmer (Bair Hugger) during spinal surgery in children.
To evaluate the efficacy of a forced-air warmer during spinal surgery for correction of scoliosis in children. ⋯ The forced-air warmer (Bair Hugger) is effective during spinal surgery, although only about 20% of body surface area can be covered.
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Randomized Controlled Trial Comparative Study Clinical Trial
Effects of subcutaneous verapamil on the duration of local anesthetic blockade.
To determine whether a subcutaneous injection of verapamil will provide local anesthesia and whether a mixture of lidocaine and verapamil will prolong the anesthetic effect of lidocaine alone. ⋯ Verapamil injected subcutaneously provides a degree of local anesthesia. However, this effect is hampered by a local reaction at the injection site and a short duration of action. The mixture of lidocaine and verapamil provides a shorter duration of action than does lidocaine alone.
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Randomized Controlled Trial Comparative Study Clinical Trial
Bair hugger forced-air warming maintains normothermia more effectively than thermo-lite insulation.
To compare the ability of forced-air warming and reflective insulation to maintain intraoperative normothermia. ⋯ Reflective insulation was unable to maintain intraoperative normothermia during total hip arthroplasty. Active warming, such as that provided by forced air, was required to prevent hypothermia.
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Randomized Controlled Trial Clinical Trial
Clinical pharmacology of rocuronium (Org 9426): study of the time course of action, dose requirement, reversibility, and pharmacokinetics.
To evaluate the time course of action, dose requirement, reversibility, and pharmacokinetics of rocuronium (Org 9426) under 3 anesthetic techniques (nitrous oxide-fentanyl supplemented with propofol, halothane, or isoflurane). ⋯ Isoflurane potentiates the rocuronium-induced neuromuscular block, resulting in a longer clinical duration and lower maintenance dose requirement. This difference is not explained by differences in pharmacokinetics but is probably due to increased sensitivity of the neuromuscular junction to rocuronium during isoflurane anesthesia.
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Randomized Controlled Trial Comparative Study Clinical Trial
Continuous administration of fentanyl for postoperative pain: a comparison of the epidural, intravenous, and transdermal routes.
To evaluate the influence of the route of administration [epidural, intravenous (IV), or transdermal] on onset and quality of analgesia and to evaluate the pharmacokinetics of continuous administration of fentanyl. ⋯ The epidural, transdermal, and IV administration of identical doses of fentanyl given at a constant rate provided almost equivalent degrees of analgesia. But continuing epidural administration produced a steady rise in systemic fentanyl concentrations into the ventilatory-depressant range, affecting the hypoxemic regulation of breathing.