Der Schmerz
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Randomized Controlled Trial Multicenter Study Comparative Study
[Effectiveness and time to onset of pregabalin in patients with neuropathic pain].
The data from a previously published 12-week randomised, double-blind, placebo-controlled multicentre study on the efficacy and safety of pregabalin were analyzed for time to onset of analgesic action with neuropathic pain. ⋯ In patients with chronic neuropathic pain, the analgesic effect of both pregabalin treatment regimens was high and associated with a rapid time to onset.
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Randomized Controlled Trial Comparative Study
[Peripheral analgesic effect of intra-articularly applied clonidine].
Clonidine applied intra-articularly into the knee joint has a peripheral analgesic effect. We examined intra-articularly injected clonidine to determine whether resorption with a measurable systemic concentration could be detected. ⋯ Intra-articular clonidine has a postoperative analgesic effect after knee arthroscopies due to a peripheral action.
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Randomized Controlled Trial Comparative Study
[Preoperative pain training. No influence on postoperative pain perception in patients undergoing cardiac surgery].
The present research was performed to investigate the influence of preoperative information on pain given by the nursing staff on postoperative pain perception in patients. ⋯ No significant modulation of postoperative pain experience was achieved by preoperative information on pain. However, it cannot be ruled out that this intervention, particularly in view of the reduction in anxiety, may form a significant element of perioperative pain management.
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[Block of the superior cervical ganglion of the Truncus sympathicus. Why it often is not possible!].
For the transoral block of the superior cervical ganglion (SCG) of the sympathetic trunk we investigated the dissemination of three of three different volumes. The aim was to find an ideal volume and reasons for a failure of the technique. ⋯ 1 ml seems to be sufficient to block the SCG. The guidelines have to be strictly followed to avoid failure of the block. 5 ml disseminate to unexpected and undesirable regions.
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Buprenorphine has been widely used and studied for over 20 years and has been shown to be an effective opioid analgesic. Some years ago a buprenorphine formulation for transdermal therapy of chronic cancer-related and non-cancer-related pain became available. ⋯ The patient has now being using the transdermal system for more than 2 years and has reported continuous excellent pain relief. The buprenorphine patch was well tolerated and produced no effect on vigilance over the whole period of administration.