NMR in biomedicine
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Quantitative susceptibility mapping (QSM) of human spinal vertebrae from a multi-echo gradient-echo (GRE) sequence is challenging, because comparable amounts of fat and water in the vertebrae make it difficult to solve the nonconvex optimization problem of fat-water separation (R2*-IDEAL) for estimating the magnetic field induced by tissue susceptibility. We present an in-phase (IP) echo initialization of R2*-IDEAL for QSM in the spinal vertebrae. Ten healthy human subjects were recruited for spine MRI. ⋯ There was no substantial difference on QSM between the single peak and multi-peak fat models, but there were marked differences among different initialization methods. The simulations demonstrated that IP provided the lowest error in the field map. Compared to Zero, VARPRO-GC and SPURS, the proposed IP method provided substantially improved spine QSM in all 10 subjects.