Cytokine
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β-adrenoceptor antagonist (β-blocker) may have potential in the treatment of septic shock and sepsis. However, the relevant research findings are still controversial. ⋯ β-blocker of esmolol is safe and effective in improving 28-day mortality and controlling ventricular rate in patients with sepsis after fluid resuscitation, and has no significant adverse effect on tissue perfusion.
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Although two meta-analysis have reported no association between the tumor necrosis factor-α (TNF-α)-308G/A polymorphism and susceptibility to pre-eclampsia (PE), recent studies showed the association was still controversial. Thus, we conduct an updated meta-analysis to elucidate this association. ⋯ Current evidence demonstrates that carriers of TNF-α (308A) allele would increase the susceptibility to PE, especially among Caucasian, Iranian and primipara.