Acta neurologica Scandinavica
-
Acta Neurol. Scand. · Oct 1992
Randomized Controlled Trial Comparative Study Clinical TrialTreatment of myotonia with antiarrhythmic drugs.
The effects of disopyramide, phenytoin, mexiletine, and tocainide were compared in 30 patients with myotonic disorders. The severity of myotonia was assessed by clinical and electromyographic criteria at the end of each treatment phase lasting four weeks. ⋯ The benefits of myotonia control with pharmacological agents must be weight against the risk of therapy in the individual patient. Because of the risks of hematologic problems, TCD is not recommended by us for the treatment of myotonia.