Acta neurologica Scandinavica
-
Acta Neurol. Scand. · Jun 2006
Multicenter Study Clinical TrialLevetiracetam in a broad population of patients with refractory epilepsy: interim results of the international SKATE trial.
To prospectively assess the safety and efficacy of levetiracetam in patients with uncontrolled focal epilepsy, in a common practice-based setting. ⋯ Levetiracetam is both efficacious and safe as an add-on therapy in patients with refractory epilepsy treated by clinicians in their daily practice.
-
Acta Neurol. Scand. · Jun 2006
Sensitivity of transcranial Doppler for confirming brain death: a prospective study of 270 cases.
The reported sensitivity of transcranial Doppler ultrasonography (TCD) for confirming brain death (BD) ranges from 91% to 100%. We assessed the frequency and causes of false-negative results in TCD examination in a series of patients with BD and in the literature. ⋯ The sensitivity of TCD for confirming BD may be lower than previously reported, but is probably similar to that of other non-invasive methods. The specificity of TCD is close to 100%. Uniform criteria are needed for the routine use of TCD as a confirmatory test for BD.
-
Acta Neurol. Scand. · Jun 2006
Randomized Controlled Trial Multicenter StudyOxcarbazepine in painful diabetic neuropathy: results of a dose-ranging study.
To evaluate the efficacy and safety of oxcarbazepine in patients with diabetic neuropathy in a multicenter, double-blind, placebo-controlled, dose-ranging 16-week study. ⋯ Although the primary efficacy variable did not reach statistical significance, patients taking oxcarbazepine 1,200 and 1,800 mg/day showed improvements in VAS scores compared with placebo. Oxcarbazepine may provide clinically meaningful pain relief in patients with painful diabetic neuropathy.