Acta neurologica Scandinavica
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Acta Neurol. Scand. · Feb 2021
Meta AnalysisCannabidiol in conjunction with clobazam: analysis of four randomized controlled trials.
To assess the efficacy and safety profile of add-on cannabidiol (CBD) in patients with Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS) on clobazam and in the overall population of four randomized, controlled phase 3 trials. ⋯ Add-on CBD was effective in reducing seizures in the overall populations and in conjunction with clobazam. Somnolence and sedation occurred more frequently in patients on CBD and clobazam.
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Acta Neurol. Scand. · Feb 2021
Epilepsy and lockdown: A survey of patients normally attending a Spanish centre.
Lockdown due to the SARS-CoV-2 pandemic became a challenge to maintain care for patients with epilepsy; we aimed to find out how the pandemic affected them. ⋯ Seizure frequency and severity remained unchanged in most patients during the lockdown. Mood and sleep disorders were common and associated with seizure worsening. Patients were open to telematic care in the future.