Acta cirúrgica brasileira
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Acta cirúrgica brasileira · Jul 2008
Phenobarbital influence on neuromuscular block produced by rocuronium in rats.
To evaluate in vitro and in vivo neuromuscular blockade produced by rocuronium in rats treated with Phenobarbital and to determine cytochrome P450 and cytochrome b5 concentrations in hepatic microsomes. ⋯ Phenobarbital alone did not compromise neuromuscular transmission. It produced enzymatic induction, and neuromuscular blockade in vivo produced by rocuronium was potentiated by phenobarbital.
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Acta cirúrgica brasileira · Jul 2008
The effects of positive end-expiratory pressure in alveolar recruitment during mechanical ventilation in pigs.
To evaluate the effects of alveolar recruitment based on mean airway pressure (MAP) on pig lungs submitted to thoracotomy through blood gas exchange and hemodynamic parameters. ⋯ PEEP adjusted to MAP of 20 cmH2O resulted in best arterial oxygenation, without compromising the venous return, as opposed to MAP of 25 cmH2O, which caused deterioration of gas exchange, hemodynamics and respiratory mechanic.