Acta cirúrgica brasileira
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Acta cirúrgica brasileira · Apr 2013
Simvastatin attenuates neutrophil recruitment in one-lung ventilation model in rats.
To investigate the anti-inflammatory effects of simvastatin in rats undergoing one-lung ventilation (OLV) followed by lung re-expansion. ⋯ In an experimental one-lung ventilation model pre-operative treatment with simvastatin reduces remote neutrophil infiltration in the continuously ventilated lung. Our findings suggest that simvastatin may be of therapeutic value in OLV-induced pulmonary inflammation deserving clinical investigations.