Acta cirúrgica brasileira
-
Acta cirúrgica brasileira · Mar 2017
Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats.
To investigate the effects of cyclosporine A on renal ischemia-reperfusion injury during transient hyperglycemia in rats. ⋯ In a model of ischemia-reperfusion-induced renal injury, cyclosporine A, 5 m.kg-1, administered five minutes before renal reperfusion in rats with acute-induced hyperglycemia under either isoflurano or propofol anesthesia, attenuated early apoptosis and preserved viability in renal tubular cells, regardless of the anesthetic used.