Acta cirúrgica brasileira
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Acta cirúrgica brasileira · Jan 2020
The effect of activated protein C in the experimental disseminated intravascular coagulation model formed by lipopolysaccharide infusion.
In this experimental study, activated protein C (APC), which has anticoagulant, antithrombotic, profibrinolytic, anti-inflammatory and antiapoptotic properties, was used to prevent coagulopathy in a disseminated intravascular coagulation (DIC) model formatted with lipopolysaccharide (LPS) infusion. ⋯ Use of APC can prevent hypercoagulation and consumption coagulopathy in the DIC as a result of correcting hematological parameters other than prolongation of coagulation time.