Acta psychiatrica Scandinavica
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Acta Psychiatr Scand · Dec 1999
Editorial Biography Historical ArticleJohn Cade's seminal lithium paper turns fifty.
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Acta Psychiatr Scand · Jun 1999
Multicenter StudyAttempted suicide and major public holidays in Europe: findings from the WHO/EURO Multicentre Study on Parasuicide.
The aim of the study was to examine the relationship between suicide attempts and major public holidays in Europe. ⋯ There appears to be a transposition of a significant number of suicide attempts from before (and during) a major public holiday until after it. The division of holidays into non-working and working days showed that a 'holiday effect' could only be found around major public holidays, particularly Christmas, Easter and Whitsun. These findings support the theory of the 'broken-promise effect' for major public holidays.
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The purpose of the present study was to investigate the comorbidity of personality disorders in patients with primary dysthymia compared to those with episodic major depression. ⋯ The data indicated that (i) dysthymia--mainly that of early onset--is associated with significantly higher personality disorder comorbidity than episodic major depression, and (ii) the presence of a personality disorder is related to more severe overall psychopathology.
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Acta Psychiatr Scand · Jun 1998
Association of maternal, antenatal and perinatal complications with suicide in adolescence and young adulthood.
The aim of the present study was to investigate whether maternal, antenatal and perinatal complications are associated with adolescent or young adulthood suicide in offspring. Cases consisted of individuals, aged 15-22 years, born in New York City and committing suicide in New York City between 1985 and 1991 (n = 189). Two controls were selected for each case, constituting the hospital birth immediately preceding and following that of the case, matched with the case with regard to sex and ethnicity. ⋯ This lack of association between complications and outcome also obtained in separate analyses by sex, ethnicity, socio-economic status and age at suicide. These results fail to replicate the findings of two previous reports implicating maternal, antenatal and perinatal complications in risk of youth suicide. At present, epidemiological evidence that adverse reproductive events increase the risk for suicide in offspring remains inconclusive.
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Acta Psychiatr Scand · Feb 1998
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialDouble-blind study of the efficacy and safety of milnacipran and imipramine in elderly patients with major depressive episode.
The novel antidepressant agent milnacipran is a dual and equipotent serotonin and noradrenaline reuptake inhibitor. The aim of this double-blind study was to compare the efficacy and safety of milnacipran (50 mg twice daily) with that of imipramine (50 mg twice daily) in elderly patients with major depressive episode. ⋯ A significantly greater number of side-effects, particularly anticholinergic effects, was observed in the imipramine group. Milnacipran may be preferable to imipramine in elderly depressed patients, as it provides the same antidepressant activity as imipramine with a lower incidence of side-effects, and does not impair cognitive ability.