Acta psychiatrica Scandinavica
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Acta Psychiatr Scand · Apr 2015
Randomized Controlled Trial Multicenter StudyNeurocognitive impairment in a large sample of homeless adults with mental illness.
This study examines neurocognitive functioning in a large, well-characterized sample of homeless adults with mental illness and assesses demographic and clinical factors associated with neurocognitive performance. ⋯ Homeless adults with mental illness experience impairment in multiple neuropsychological domains. Much of the variance in our sample's cognitive performance remains unexplained, highlighting the need for further research in the mechanisms underlying cognitive impairment in this population.
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Acta Psychiatr Scand · Nov 2013
Multicenter Study Comparative StudyThe bipolar-borderline personality disorders connection in major depressive patients.
The study focuses on the controversial relationship between borderline personality disorder (BPD) and bipolar disorder (BD), defined according to different criteria set, in a world-wide sample of patients with a current major depressive episode (MDE). ⋯ In our sample, selected on the basis of the presence of a mood disorder, the BD-BPD connection is confirmed by the high prevalence of bipolarity in depressive patients with BPD and by the significant association with familial and clinical features classically considered as external validators of bipolarity.
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Acta Psychiatr Scand · Sep 2006
Randomized Controlled Trial Multicenter StudyUnderstanding suicidal ideation in psychosis: findings from the Psychological Prevention of Relapse in Psychosis (PRP) trial.
To examine the clinically important phenomenon of suicidal ideation in psychosis in relation to affective processes and the multidimensional nature of hallucinations and delusions. ⋯ Affective dysfunction, including distress in response to hallucinations and delusions, was a key factor associated with suicidal ideation in individuals with psychotic relapse. Suicidal ideation in psychosis appears to be an understandable, mood-driven process, rather than being of irrational or 'psychotic' origin.
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Acta Psychiatr Scand · Jun 1999
Multicenter StudyAttempted suicide and major public holidays in Europe: findings from the WHO/EURO Multicentre Study on Parasuicide.
The aim of the study was to examine the relationship between suicide attempts and major public holidays in Europe. ⋯ There appears to be a transposition of a significant number of suicide attempts from before (and during) a major public holiday until after it. The division of holidays into non-working and working days showed that a 'holiday effect' could only be found around major public holidays, particularly Christmas, Easter and Whitsun. These findings support the theory of the 'broken-promise effect' for major public holidays.
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Acta Psychiatr Scand · Feb 1998
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialDouble-blind study of the efficacy and safety of milnacipran and imipramine in elderly patients with major depressive episode.
The novel antidepressant agent milnacipran is a dual and equipotent serotonin and noradrenaline reuptake inhibitor. The aim of this double-blind study was to compare the efficacy and safety of milnacipran (50 mg twice daily) with that of imipramine (50 mg twice daily) in elderly patients with major depressive episode. ⋯ A significantly greater number of side-effects, particularly anticholinergic effects, was observed in the imipramine group. Milnacipran may be preferable to imipramine in elderly depressed patients, as it provides the same antidepressant activity as imipramine with a lower incidence of side-effects, and does not impair cognitive ability.