Journal of child and adolescent psychopharmacology
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J Child Adolesc Psychopharmacol · Apr 2019
Meta AnalysisAtypical Antipsychotics for Irritability in Pediatric Autism: A Systematic Review and Network Meta-Analysis.
Irritability is common in pediatric autism spectrum disorder (ASD) patients. This can have major implications in child development, receptivity to behavioral therapy, as well as child and caregiver well-being. A systematic review and network meta-analysis were conducted to assess the efficacy and safety of atypical antipsychotics in treating irritability in these patients. ⋯ Risperidone and aripiprazole were the two best drugs, with comparable efficacy and safety in pediatric ASD patients. These two medications could be beneficial in improving irritability in these patients.