Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · Aug 2019
Probing structure of normal and malignant prostate tissue before and after radiation therapy with luminal water fraction and diffusion-weighted MRI.
Interpretation of diffusion in conjunction with T2 -weighted MRI is essential for assessing prostate cancer; however, the combination of apparent diffusion coefficient (ADC) with quantitative T2 mapping remains unexplored. ⋯ 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:619-627.
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J Magn Reson Imaging · Aug 2019
Fast myocardial T1 mapping using shortened inversion recovery based schemes.
Myocardial T1 mapping shows promise for assessment of cardiomyopathies. Most myocardial T1 mapping techniques, such as modified Look-Locker inversion recovery (MOLLI), generate one T1 map per breath-held acquisition (9-17 heartbeats), which prolongs multislice protocols and may be unsuitable for patients with breath-holding difficulties. ⋯ 1 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2019;50:641-654.
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J Magn Reson Imaging · Aug 2019
T2 -based MRI Delta-radiomics improve response prediction in soft-tissue sarcomas treated by neoadjuvant chemotherapy.
Standard of care for patients with high-grade soft-tissue sarcoma (STS) are being redefined since neoadjuvant chemotherapy (NAC) has demonstrated a positive effect on patients' outcome. Yet response evaluation in clinical trials still relies on RECIST criteria. ⋯ 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:497-510.
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J Magn Reson Imaging · Jul 2019
Observational StudyIncreased mean R2* in the deep gray matter of multiple sclerosis patients: Have we been measuring atrophy?
Magnetic resonance relaxometry studies in multiple sclerosis (MS) have suggested that iron accumulates within deep gray matter (DGM) structures early in the disease course. However, the commonly utilized mean R2* and magnetic susceptibility measures reflect regional iron concentration but not a structure's total iron content. Thus, tissue atrophy could impact mean R2* and magnetic susceptibility estimates. ⋯ 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:201-208.
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J Magn Reson Imaging · Jul 2019
Comparative StudyDirect comparison between apparent diffusion coefficient and macromolecular proton fraction as quantitative biomarkers of the human fetal brain maturation.
Apparent diffusion coefficient (ADC) is known as a quantitative biomarker of prenatal brain maturation. Fast macromolecular proton fraction (MPF) mapping is an emerging method for quantitative assessment of myelination that was recently adapted to fetal MRI. ⋯ 2 Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2019;50:52-61.