Current biology : CB
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Current biology : CB · Mar 2019
Rat Orbitofrontal Ensemble Activity Contains Multiplexed but Dissociable Representations of Value and Task Structure in an Odor Sequence Task.
The orbitofrontal cortex (OFC) has long been implicated in signaling information about expected outcomes to facilitate adaptive or flexible behavior. Current proposals focus on signaling of expected value versus the representation of a value-agnostic cognitive map of the task. While often suggested as mutually exclusive, these alternatives may represent extreme ends of a continuum determined by task complexity and experience. ⋯ Consistent with the hypothesis that the OFC represents a cognitive map tailored to the subjects' intentions or plans, we found a close correspondence between how subjects were using the sequences and the neural representations of the sequences in OFC ensembles. Multiplexed with this value-invariant representation of the task, we also found a representation of the expected value at each location. Thus, the value and task structure co-existed as dissociable components of the neural code in OFC.