Current biology : CB
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Most of Earth's surface is blue or white, but how much of each would depend on the time of observation. Our planet has been through phases of snowball (all frozen), greenhouse (all liquid seas) and icehouse (frozen and liquid). Even during current icehouse conditions, the extent of ice versus water has changed considerably between ice ages and interglacial periods. ⋯ However, they are also regions of striking contrasts: the Arctic Ocean is near surrounded by land compared with the Antarctic continent, which is surrounded by the Southern Ocean. Polar oceans contrast in size, age, isolation, depth, oceanography, biology and human factors, such as governance and human habitation. The simplest foodwebs with the smallest residents live on the 1% of Antarctica that is ice free, whilst the largest animals that have ever lived on Earth (Blue and Fin whales) feed in the Arctic and Southern Oceans.
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Current biology : CB · Mar 2017
Frogs Exploit Statistical Regularities in Noisy Acoustic Scenes to Solve Cocktail-Party-like Problems.
Noise is a ubiquitous source of errors in all forms of communication [1]. Noise-induced errors in speech communication, for example, make it difficult for humans to converse in noisy social settings, a challenge aptly named the "cocktail party problem" [2]. Many nonhuman animals also communicate acoustically in noisy social groups and thus face biologically analogous problems [3]. ⋯ In four psychophysical experiments, we investigated whether females exploit comodulation in background noise to mitigate noise-induced errors in evolutionarily critical mate-choice decisions. Subjects experienced fewer errors in recognizing conspecific calls and in selecting the calls of high-quality mates in the presence of simulated chorus noise that was comodulated. These data show unequivocally, and for the first time, that exploiting statistical regularities present in noisy acoustic scenes is an important biological strategy for solving cocktail-party-like problems in nonhuman animal communication.
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Current biology : CB · Feb 2017
Historical ArticleViral Evolution: Mummy Virus Challenges Presumed History of Smallpox.
Despite evidence of smallpox in antiquity, a new study of a 350 year-old Lithuanian child mummy suggests that the global viral genetic diversity circulating during the 20th century was only around 200 years old.
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Current biology : CB · Dec 2016
Historical Article17th Century Variola Virus Reveals the Recent History of Smallpox.
Smallpox holds a unique position in the history of medicine. It was the first disease for which a vaccine was developed and remains the only human disease eradicated by vaccination. Although there have been claims of smallpox in Egypt, India, and China dating back millennia [1-4], the timescale of emergence of the causative agent, variola virus (VARV), and how it evolved in the context of increasingly widespread immunization, have proven controversial [4-9]. ⋯ When compared to vaccinia virus, this archival strain contained the same pattern of gene degradation as 20th century VARVs, indicating that such loss of gene function had occurred before ca. 1650. Strikingly, the mummy sequence fell basal to all currently sequenced strains of VARV on phylogenetic trees. Molecular-clock analyses revealed a strong clock-like structure and that the timescale of smallpox evolution is more recent than often supposed, with the diversification of major viral lineages only occurring within the 18th and 19th centuries, concomitant with the development of modern vaccination.
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Current biology : CB · Aug 2016
Glutamatergic Neurotransmission Links Sensitivity to Volatile Anesthetics with Mitochondrial Function.
An enigma of modern medicine has persisted for over 150 years. The mechanisms by which volatile anesthetics (VAs) produce their effects (loss of consciousness, analgesia, amnesia, and immobility) remain an unsolved mystery. Many attractive putative molecular targets have failed to produce a significant effect when genetically tested in whole-animal models [1-3]. ⋯ Spontaneous inhibitory postsynaptic currents (sIPSCs) were not differentially affected between genotypes. The effects of isoflurane were similar on evoked field excitatory postsynaptic potentials (fEPSPs) and paired pulse facilitation (PPF) in KO and control hippocampal slices. We propose that CA1 presynaptic excitatory neurotransmission is hypersensitive to isoflurane in Ndufs4(KO) mice due to the inhibition of pre-existing reduced complex I function, reaching a critical reduction that can no longer meet metabolic demands.