Hip international : the journal of clinical and experimental research on hip pathology and therapy
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Randomized Controlled Trial
Combined use of intravenous and topical tranexamic acid following cementless total hip arthroplasty: a randomised clinical trial.
This study was designed to compare the efficacy and safety of the combined use of tranexamic acid (TXA) with the intravenous (IV) or local use alone in total hip arthroplasty (THA). ⋯ Combined use of intravenous TXA and local TXA in primary unilateral THA can effectively decrease total blood loss and increase postoperative haemoglobin levels without influencing complication rates. It is suggested that this combined TXA regimen is more effective in decreasing blood loss in cementeless THA than intravenous or local administration alone.