Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
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Cancer Epidemiol. Biomarkers Prev. · Oct 2013
Randomized Controlled TrialRandomized controlled trial of a sun protection intervention for children of melanoma survivors.
We studied whether a melanoma survivor-centered intervention was more effective than materials available to the general public in increasing children's sun protection. ⋯ This is the first study to examine a sun protection intervention for children of melanoma survivors. Findings will guide interventions for this important population at increased melanoma risk.
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Cancer Epidemiol. Biomarkers Prev. · Oct 2013
Plasma C-peptide, mammographic breast density, and risk of invasive breast cancer.
Insulin may promote breast cancer directly by stimulating the insulin receptor or indirectly by increasing the plasma concentration of active sex hormones. The association between insulin and breast density, a strong breast cancer risk factor, has not been thoroughly studied. We measured associations between c-peptide (a molar marker of insulin secretion), breast cancer risk, and breast density measurements in case-control studies nested within the Nurses' Health Study and Nurses' Health Study II cohorts. ⋯ Primary prevention of breast cancer in women with hyperinsulinemia may be possible by targeting insulin signaling pathways.
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Cancer Epidemiol. Biomarkers Prev. · Oct 2013
Impact of rural residence on forgoing healthcare after cancer because of cost.
Routine follow-up care is recommended to promote the well-being of cancer survivors, but financial difficulties may interfere. Rural-urban disparities in forgoing healthcare due to cost have been observed in the general population; however, it is unknown whether this disparity persists among survivors. The purpose of this study was to examine rural-urban disparities in forgoing healthcare after cancer due to cost. ⋯ Addressing out-of-pocket costs may be an important step in reducing rural-urban disparities in healthcare, especially for older survivors. It will be important to monitor how healthcare reform efforts impact disparities observed in this vulnerable population.
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Cancer Epidemiol. Biomarkers Prev. · Oct 2013
Molecular signatures of epithelial ovarian cancer: analysis of associations with tumor characteristics and epidemiologic risk factors.
Six gene expression subtypes of invasive epithelial ovarian cancer were recently defined using microarrays by Tothill and colleagues. The Cancer Genome Atlas (TCGA) project subsequently replicated these subtypes and identified a signature predictive of survival in high-grade serous (HGS) cancers. We previously validated these signatures for use in formalin-fixed paraffin-embedded tissues. The aim of the present study was to determine whether these signatures are associated with specific ovarian cancer risk factors, which would add to the evidence that they reflect the heterogeneous etiology of this disease. ⋯ This study suggests that molecular signatures may augment the ability to define etiologic subtypes of epithelial ovarian cancer.