Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
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Cancer Epidemiol. Biomarkers Prev. · May 2014
ReviewGastric cancer: descriptive epidemiology, risk factors, screening, and prevention.
Less than a century ago, gastric cancer was the most common cancer in the United States and perhaps throughout the world. Despite its worldwide decline in incidence over the past century, gastric cancer remains a major killer across the globe. This article reviews the epidemiology, screening, and prevention of gastric cancer. ⋯ Next, we characterize the risk factors for gastric cancer, both environmental and genetic. Serologic markers and histological precursor lesions of gastric cancer and early detection of gastric cancer using these markers are reviewed. Finally, we discuss prevention strategies and provide suggestions for further research.
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Cancer Epidemiol. Biomarkers Prev. · May 2014
Intrinsic subtypes from PAM50 gene expression assay in a population-based breast cancer cohort: differences by age, race, and tumor characteristics.
Data are lacking to describe gene expression-based breast cancer intrinsic subtype patterns for population-based patient groups. ⋯ Subtyping in a population-based cohort revealed distinct profiles by age and race.
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Cancer Epidemiol. Biomarkers Prev. · May 2014
Intrinsic subtypes from the PAM50 gene expression assay in a population-based breast cancer survivor cohort: prognostication of short- and long-term outcomes.
The PAM50, a gene expression assay to categorize breast tumors into intrinsic subtypes, has not been previously used to examine short- and long-term prognostication in a population-based cohort where treatment patterns and time of initial follow-up vary. ⋯ The PAM50 is robust for use in epidemiologic studies and should be considered when archived tumor tissues are available.