Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
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Cancer Epidemiol. Biomarkers Prev. · Jul 2014
The global burden of disease for skin, lung, and bladder cancer caused by arsenic in food.
Arsenic is a ubiquitous, naturally occurring metalloid that poses a significant human cancer risk. While water consumption provides the majority of human exposure, millions of individuals worldwide are significantly exposed to arsenic through naturally occurring levels of arsenic in grains, vegetables, meats and fish, as well as through food processed with water containing arsenic. Thus, we estimated the global burdens of disease for bladder, lung, and skin cancers attributable to inorganic arsenic in food. ⋯ Estimating the global cancer burden caused by arsenic exposure in food will support policies that reduce exposure to disease-promoting environmental hazards.
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Cancer Epidemiol. Biomarkers Prev. · Jul 2014
Risk of hospitalization for survivors of childhood and adolescent cancer.
Childhood cancer survivors may be at increased risk of hospitalization because of cancer-related late effects. ⋯ Research to identify strategies to prevent and manage survivors' health problems in outpatient settings is needed.
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Cancer Epidemiol. Biomarkers Prev. · May 2014
ReviewGastric cancer: descriptive epidemiology, risk factors, screening, and prevention.
Less than a century ago, gastric cancer was the most common cancer in the United States and perhaps throughout the world. Despite its worldwide decline in incidence over the past century, gastric cancer remains a major killer across the globe. This article reviews the epidemiology, screening, and prevention of gastric cancer. ⋯ Next, we characterize the risk factors for gastric cancer, both environmental and genetic. Serologic markers and histological precursor lesions of gastric cancer and early detection of gastric cancer using these markers are reviewed. Finally, we discuss prevention strategies and provide suggestions for further research.
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Cancer Epidemiol. Biomarkers Prev. · May 2014
Intrinsic subtypes from PAM50 gene expression assay in a population-based breast cancer cohort: differences by age, race, and tumor characteristics.
Data are lacking to describe gene expression-based breast cancer intrinsic subtype patterns for population-based patient groups. ⋯ Subtyping in a population-based cohort revealed distinct profiles by age and race.
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Cancer Epidemiol. Biomarkers Prev. · May 2014
Intrinsic subtypes from the PAM50 gene expression assay in a population-based breast cancer survivor cohort: prognostication of short- and long-term outcomes.
The PAM50, a gene expression assay to categorize breast tumors into intrinsic subtypes, has not been previously used to examine short- and long-term prognostication in a population-based cohort where treatment patterns and time of initial follow-up vary. ⋯ The PAM50 is robust for use in epidemiologic studies and should be considered when archived tumor tissues are available.