The Annals of pharmacotherapy
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To describe the use of parenteral ketorolac in a large population of children, focusing on dosing patterns, efficacy, and safety. ⋯ Ketorolac appears to be a safe and effective therapy for children when given in appropriate doses for a limited duration.
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Comparative Study
Acetylcysteine as a cytoprotective antioxidant in patients with severe sepsis: potential new use for an old drug.
To stimulate debate regarding a potential new use for acetylcysteine as a cellular antioxidant in severely septic patients with systemic inflammatory response syndrome (SIRS). ⋯ The data do not as yet lead to any firm conclusions regarding the value of acetylcysteine in the management of SIRS in severe sepsis. The animal and human studies are, however, sufficiently encouraging to warrant formal trials to test the hypothesis that acetylcysteine therapy has a cytoprotective effect in sepsis.