The Annals of pharmacotherapy
-
Clinical Trial
Thrombocytopenia in intensive care patients: a comprehensive analysis of risk factors in 314 patients.
To define the incidence and severity of thrombocytopenia in a mixed medical-surgical population of critically ill patients and to examine factors that may be related to the development of thrombocytopenia. ⋯ Thrombocytopenia in the critically ill occurs frequently, rarely reaches severely depressed concentrations, and primarily represents a manifestation of disease processes initiated prior to admission. Hemodynamic instability and/or heparin exposure appear to be the strongest identifiable correlates with thrombocytopenia. Although these may cause infrequent isolated cases, other specific drug causes of thrombocytopenia are not responsible for the majority of cases of thrombocytopenia in the critically ill.
-
Letter Case Reports
Effect of dexamethasone on the decrease of serum phenytoin concentrations.