The Annals of pharmacotherapy
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Randomized Controlled Trial Comparative Study Clinical Trial
Patient-controlled analgesia versus patient-controlled analgesia plus continuous infusion after hip replacement surgery.
To compare the efficacy and adverse effect profile of patient-controlled analgesia (PCA) versus PCA plus continuous infusion (PCACI) after hip replacement surgery. ⋯ When compared with PCA therapy, PCACI was not associated with improved pain control and more patients receiving PCACI required discontinuation of therapy secondary to adverse effects.
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Comparative Study
Predicting unbound phenytoin concentrations in the critically ill neurosurgical patient.
To assess the correlation of measured unbound phenytoin concentration (dphF) to estimated unbound concentration (dphEF) using the Sheiner-Tozer equation in critically ill patients in the neurosurgical intensive care unit. ⋯ These results indicate that, in this population, the Sheiner-Tozer estimate of dphEF provides an unbiased, precise clinical estimate of dphF in patients for whom measured dphF is unavailable or impractical.
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To report a case of suspected neuroleptic malignant syndrome (NMS) associated with clozapine therapy. ⋯ NMS may be a possible complication of clozapine therapy.
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Propofol appears to possess antiemetic actions. Limited reports have shown benefit with its use as adjuvant therapy with highly emetogenic chemotherapy regimens and as monotherapy with moderately emetogenic chemotherapy. ⋯ Results from well-designed, controlled clinical trials in large numbers of patients are needed to define the appropriate role of propofol in antiemetic therapy. Currently, propofol must be reserved for use in clinical trials or as adjuvant therapy for patients refractory to standard 5-HT3 antagonist and corticosteroid antiemetic prophylaxis.