The Annals of pharmacotherapy
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To report a case of torsade de pointes related to the administration of high-dose intravenous haloperidol for the treatment of severe agitation. ⋯ Our case report and others from the literature suggest that intravenous haloperidol administration may prolong QT intervals in some patients, precipitating the potentially life-threatening arrhythmia torsade de pointes. Clinicians should be aware of haloperidol's potential to induce torsade de pointes, since it is used regularly for agitation and delirium in the critical care arena.