The Annals of pharmacotherapy
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Randomized Controlled Trial Comparative Study Clinical Trial
Intrathecal morphine after cardiac surgery.
To assess whether intrathecal (IT) analgesia facilitates early extubation and provides superior pain control after cardiac surgery compared with patient-controlled analgesia (PCA) or nurse-administered SC injections. ⋯ Considering that the administration of IT morphine is more costly and can be riskier than conventional analgesic regimens, we conclude that its use is not indicated in patients undergoing cardiac surgery if early extubation is planned.
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To review the efficacy and safety of drotrecogin alfa (recombinant human activated protein C) in the treatment of sepsis. ⋯ Drotrecogin alfa offers a significant advance in the treatment of severe sepsis. Judicious use in appropriate patients is necessary to control cost and maximize clinical benefits.
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To describe the clinical presentation of propofol infusion syndrome in critically ill adults. ⋯ Until further safety data become available, caution should be exercised when using high-dose (>5 mg/kg/h) and long-term (>48 h) propofol infusion in sedating critically ill adults.