The Annals of pharmacotherapy
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Review Comparative Study
Antipyretic efficacy and safety of ibuprofen and acetaminophen in children.
To evaluate the antipyretic effects and safety of ibuprofen compared with acetaminophen in febrile children. ⋯ The efficacy and effectiveness of acetaminophen and ibuprofen in their recommended dosages are similar, with slightly more beneficial effects shown with ibuprofen.
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Multicenter Study
Venous thromboembolic prophylaxis in hospitalized medical patients.
The risk for venous thromboembolism (VTE) in medical patients is similar to that in moderate-risk surgery patients. Pharmacologic thromboprophylaxis is recommended for certain medical patients, but its use in clinical practice is unknown. ⋯ There is significant underutilization of VTE prophylaxis in this patient population. Patients are not adequately assessed for bleeding risk factors, and a portion of prescribed regimens are not those that have been established in the literature. Expert consensus statements recommend that hospitals develop strategies to prevent VTE events in their patients. Strategies to improve patient screening and physicians' prescribing habits are needed.
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To report a case of delirium with hallucinations presumably caused by the combination of diphenhydramine and linezolid. ⋯ Drug-induced delirium can occur with several drugs, including diphenhydramine. Linezolid has dopaminergic properties that may enhance the central nervous system effects of anticholinergics. Precautionary monitoring of mental status should be advised when concomitantly administering linezolid with drugs in this class.