The Annals of pharmacotherapy
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To evaluate the efficacy and safety of the polypill for prevention of cardiovascular disease (CVD) and stroke and to present literature related to the polypill components (statin, aspirin, antihypertensive) for primary prevention of CVD and stroke. ⋯ Polypill study results have been more modest than originally theorized. However, results show promise in patients at higher risk for CVD and stroke.