The Annals of pharmacotherapy
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To review the prospective controlled trials available for the use of melatonin receptor agonists for delirium prevention. ⋯ The routine use of melatonin receptor agonists for delirium prevention cannot be recommended at this time.
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In septic shock, the dose of norepinephrine (NE) at which vasopressin (AVP) should be added is unknown. Following an increase in AVP price, our medical intensive care unit (MICU) revised its vasopressor guidelines to reserve AVP for patients requiring greater than 50 µg/min of NE. ⋯ Use of a vasopressor guideline restricting AVP initiation in septic patients to those on at least 50 µg/min of NE appeared to be safe and did not affect the time to reach goal MAP.
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Postoperative pain is a common complication of laparoscopic living-donor nephrectomies (LLDNs). ⋯ Patients receiving IV acetaminophen were found to have no improvements in hospital LOS, average pain score, or opioid requirements compared with patients not receiving IV acetaminophen. Patients who received IV acetaminophen were also found to have a higher 30-day readmission rate.