The Annals of pharmacotherapy
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To report a case of venlafaxine overdose. ⋯ The venlafaxine overdose in our patient resulted in a single episode of generalized seizure but elicited no further sequelae.
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To report a possible case of serotonin syndrome associated with coadministration of tramadol hydrochloride and sertraline hydrochloride. ⋯ Clinicians should be aware of the potential for serotonin syndrome with concomitant administration of sertraline and tramadol.
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To report a case of rhabdomyolysis associated with epsilon-aminocaproic acid (epsilon-ACA). ⋯ Long-term therapy with high-dose epsilon-ACA may produce muscle weakness or rhabdomyolysis. Patients who require long-term, high-dose epsilon-ACA therapy should be monitored for myoglobinuria and changes in serum CK, LDH, and AST, for myoglobinemia, for decreases in muscle strength, and/or for myalgia. Significant changes in these parameters compared with baseline values should suggest a need to discontinue epsilon-ACA therapy.