Pharmacoepidemiology and drug safety
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Pharmacoepidemiol Drug Saf · Nov 2014
ReviewMortality rate in so-called "metformin-associated lactic acidosis": a review of the data since the 1960s.
The aim of this study is to study the mortality rate in so-called "metformin-associated lactic acidosis" (MALA) from the 1960s to date and to establish whether the rate has changed over time. ⋯ The overall mortality rate for MALA was around 50% during the period 1960-2000 but has since fallen to around 25%.
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Pharmacoepidemiol Drug Saf · Nov 2014
Cardiovascular and mortality risks in older Medicare patients treated with varenicline or bupropion for smoking cessation: an observational cohort study.
To compare cardiovascular and mortality risks in elderly patients treated with varenicline or bupropion for smoking cessation. ⋯ Cardiovascular and mortality risks were not increased in older patients treated with varenicline compared with bupropion for smoking cessation. A potential increase in the risk of stroke with varenicline could not be excluded. Treatment persistence with either drug was low. Published 2014. This article is a U.S. Government work and is in the public domain in the USA.
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Pharmacoepidemiol Drug Saf · Nov 2014
Risk of Guillain-Barré syndrome following pandemic influenza A(H1N1) 2009 vaccination in Germany.
A prospective, epidemiologic study was conducted to assess whether the 2009 pandemic influenza A(H1N1) vaccination in Germany almost exclusively using an AS03-adjuvanted vaccine (Pandemrix) impacts the risk of Guillain-Barré syndrome (GBS) and its variant Fisher syndrome (FS). ⋯ The results indicate an increased risk of GBS/FS in temporal association with pandemic influenza A(H1N1) vaccination in Germany.