Neuroimaging clinics of North America
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In neuroimaging research, averaging data at the level of the group results in blurring of potentially meaningful individual differences. A more widespread use of an individual-specific approach is advocated for, which involves a more thorough investigation of each individual in a group, and characterization of idiosyncrasies at the level of behavior, cognition, and symptoms, as well as at the level of brain organization. It is hoped that such an approach, focused on individuals, will provide convergent findings that will help identify the underlying pathologic condition in various psychiatric disorders and help in the development of treatments individualized for each patient.
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Neuroimaging Clin. N. Am. · Feb 2020
ReviewThe Neurodevelopment of Autism from Infancy Through Toddlerhood.
Autism spectrum disorder (ASD) emerges during early childhood and is marked by a relatively narrow window in which infants transition from exhibiting normative behavioral profiles to displaying the defining features of the ASD phenotype in toddlerhood. Prospective brain imaging studies in infants at high familial risk for autism have revealed important insights into the neurobiology and developmental unfolding of ASD. In this article, we review neuroimaging studies of brain development in ASD from birth through toddlerhood, relate these findings to candidate neurobiological mechanisms, and discuss implications for future research and translation to clinical practice.
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Neuroimaging Clin. N. Am. · Feb 2020
ReviewMagnetic Resonance Spectroscopy for Psychiatry: Progress in the Last Decade.
Psychiatric disorders are common and can be severe. There is a need to identify biomarkers of psychiatric disorders to better diagnose and treat patients with psychiatric symptoms. ⋯ There have been significant advances in the way that psychiatric disorders are understood, classified, and researched as well as improvements in magnetic resonance imaging/MRS technology. MRS as a tool has not yet proved helpful to individual patients with psychiatric symptoms.
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Neuroimaging Clin. N. Am. · Feb 2020
ReviewPsychoradiological Biomarkers for Psychopharmaceutical Effects.
The application of personalized medicine to psychiatry is challenging. Psychoradiology could provide biomarkers based on objective tests in support of the diagnostic classifications and treatment planning. ⋯ Although none of the biomarkers reviewed are yet of sufficient clinical utility to inform the selection of a specific pharmacologic compound for an individual patient, there is strong consensus that advanced multimodal approaches will contribute to discovery of novel treatment predictors in psychiatric disorders. Progress has been sufficient to warrant enthusiasm, in which application of neuroimaging-based biomarkers would represent a paradigm shift and modernization of psychiatric practice.
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Schizophrenia is a chronic psychotic disorder with a lifetime prevalence of about 1%. Onset is typically in adolescence or early adulthood; characteristic symptoms include positive symptoms, negative symptoms, and impairments in cognition. ⋯ These abnormalities are not sufficiently specific to be of diagnostic value, but there may be a role for imaging techniques to provide predictions of outcome. Incorporating multimodal imaging datasets using machine learning approaches may offer better diagnostic and predictive value in schizophrenia.