Neuroimaging clinics of North America
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Neuroimaging Clin. N. Am. · May 2020
ReviewMerging Magnetoencephalography into Epilepsy Presurgical Work-up Under the Framework of Multimodal Integration.
Multimodal image integration is the procedure that puts together imaging data from multiple sources into the same space by a computerized registration process. This procedure is relevant to patients with difficult-to-localize epilepsy undergoing presurgical evaluation, who typically have many tests performed, including MR imaging, PET, ictal single-photon emission computed tomography, magnetoencephalography (MEG), and intracranial electroencephalogram (EEG). This article describes the methodology of such integration, focusing on integration of MEG. Also discussed is the clinical value of integration of MEG, in terms of planning of intracranial EEG implantation, interpretation of intracranial EEG data, planning of final resection, and addressing surgical failures.
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Neuroimaging Clin. N. Am. · May 2020
ReviewPediatric Magnetoencephalography in Clinical Practice and Research.
Magnetoencephalography (MEG) is a noninvasive neuroimaging technique that measures the electromagnetic fields generated by the human brain. This article highlights the benefits that pediatric MEG has to offer to clinical practice and pediatric research, particularly for infants and young children; reviews the existing literature on adult MEG systems for pediatric use; briefly describes the few pediatric MEG systems currently extant; and draws attention to future directions of research, with focus on the clinical use of MEG for patients with drug-resistant epilepsy.
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In neuroimaging research, averaging data at the level of the group results in blurring of potentially meaningful individual differences. A more widespread use of an individual-specific approach is advocated for, which involves a more thorough investigation of each individual in a group, and characterization of idiosyncrasies at the level of behavior, cognition, and symptoms, as well as at the level of brain organization. It is hoped that such an approach, focused on individuals, will provide convergent findings that will help identify the underlying pathologic condition in various psychiatric disorders and help in the development of treatments individualized for each patient.
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Neuroimaging Clin. N. Am. · Feb 2020
ReviewThe Neurodevelopment of Autism from Infancy Through Toddlerhood.
Autism spectrum disorder (ASD) emerges during early childhood and is marked by a relatively narrow window in which infants transition from exhibiting normative behavioral profiles to displaying the defining features of the ASD phenotype in toddlerhood. Prospective brain imaging studies in infants at high familial risk for autism have revealed important insights into the neurobiology and developmental unfolding of ASD. In this article, we review neuroimaging studies of brain development in ASD from birth through toddlerhood, relate these findings to candidate neurobiological mechanisms, and discuss implications for future research and translation to clinical practice.
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Neuroimaging Clin. N. Am. · Feb 2020
ReviewMagnetic Resonance Spectroscopy for Psychiatry: Progress in the Last Decade.
Psychiatric disorders are common and can be severe. There is a need to identify biomarkers of psychiatric disorders to better diagnose and treat patients with psychiatric symptoms. ⋯ There have been significant advances in the way that psychiatric disorders are understood, classified, and researched as well as improvements in magnetic resonance imaging/MRS technology. MRS as a tool has not yet proved helpful to individual patients with psychiatric symptoms.