Neuroimaging clinics of North America
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Neuroimaging Clin. N. Am. · May 2020
ReviewPediatric Magnetoencephalography in Clinical Practice and Research.
Magnetoencephalography (MEG) is a noninvasive neuroimaging technique that measures the electromagnetic fields generated by the human brain. This article highlights the benefits that pediatric MEG has to offer to clinical practice and pediatric research, particularly for infants and young children; reviews the existing literature on adult MEG systems for pediatric use; briefly describes the few pediatric MEG systems currently extant; and draws attention to future directions of research, with focus on the clinical use of MEG for patients with drug-resistant epilepsy.
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Neuroimaging Clin. N. Am. · May 2020
ReviewRole of Magnetoencephalography in the Early Stages of Alzheimer Disease.
As synaptic dysfunction is an early manifestation of Alzheimer disease (AD) pathology, magnetoencephalography (MEG) is capable of detecting disruptions by assessing the synchronized oscillatory activity of thousands of neurons that rely on the integrity of neural connections. MEG findings include slowness of the oscillatory activity, accompanied by a reduction of the alpha band power, and dysfunction of the functional networks. ⋯ These neurophysiological biomarkers predict which patients with mild cognitive impairment will develop dementia. MEG has demonstrated its utility as a noninvasive biomarker for early detection of AD.
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Neuroimaging Clin. N. Am. · Feb 2020
ReviewImplementing MR Imaging into Clinical Routine Screening in Patients with Psychosis?
MR imaging is a suitable instrument for the detection of incidental radiological findings in patients with early psychosis and guidance of subsequent treatment adjustments. We outline evidence showing the clinical utility of MR imaging to guide treatment selection by identifying radiological abnormalities and predicting clinical outcomes in early-stage psychosis. We argue that MR imaging is an indispensable screening tool to detect gross radiological abnormalities in early psychosis and implementation in routine clinical assessments is warranted. We highlight future key challenges and make pragmatic suggestions to exploit the potential of MR imaging to construct robust prognostic models for personalized early interventions.