Physiological measurement
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Physiological measurement · May 2010
Intracranial pressure pulse morphological features improved detection of decreased cerebral blood flow.
We investigated whether intracranial pressure (ICP) pulse morphological metrics could be used to realize continuous detection of low cerebral blood flow. Sixty-three acutely brain injured patients with ICP monitoring, daily (133)Xenon cerebral blood flow (CBF) and daily transcranial Doppler (TCD) assessments were studied. Their ICP recordings were time-aligned with the CBF and TCD measurements so that a 1 h ICP segment near the CBF and TCD measurements was obtained. ⋯ However, using the optimal combination of the MOCAIP metrics alone we were able to achieve a sensitivity of 92.5 +/- 0.7% and a specificity of 84.8 +/- 0.8%. Searching the optimal combination of all available metrics, we achieved the best result that was marginally better than those from using MOCAIP alone. This study demonstrated that the potential role of ICP monitoring may be extended to provide an indicator of low global cerebral blood perfusion.