Physiological measurement
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Physiological measurement · Oct 2011
Lack of consistent intracranial pressure pulse morphological changes during episodes of microdialysis lactate/pyruvate ratio increase.
Lactate/pyruvate ratio (LPR) from microdialysis is a well-established marker of cerebral metabolic crisis. For brain injury patients, abnormally high LPR could indicate cerebral ischemia or failure of O(2) uptake. However, there is a debate on the primary factor responsible for LPR increase. ⋯ Even for the few subjects who have at least one ICP metric with a consistent trend during the LPR increase episodes, the number of such metrics is small and varies from subject to subject. Given the fact that ICP pulse morphology is influenced by the cerebral vasculature, our results suggest that a dominant cerebral vascular cause may be behind the changes in LPR when LPR trends correlate with ICP pulse morphological changes. However, the incidence of such correlation seems to be low.