Anaesthesia
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Randomized Controlled Trial Comparative Study Clinical Trial
A comparison between isoflurane and alfentanil supplemented anaesthesia for short procedures.
Sixty unpremedicated patients undergoing short urological and gynaecological procedures were randomly allocated to three groups to receive either methohexitone, alfentanil, nitrous oxide and oxygen, methohexitone, isoflurane and oxygen or methohexitone, isoflurane, nitrous oxide and oxygen. The group receiving methohexitone, isoflurane and oxygen was abandoned after 11 patients had been studied, due to poor conditions during induction of anaesthesia. Therefore, data from only 51 patients are presented. ⋯ The patients in the alfentanil group opened their eyes and gave their names and dates of birth significantly faster postoperatively (p less than 0.01) than those in the isoflurane groups. However, there were no significant differences between the three groups regarding the later tests of recovery. The late recovery after isoflurane was equal to that obtained using an intravenous technique with alfentanil, although the peroperative complication rate was higher.
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Randomized Controlled Trial Comparative Study Clinical Trial
Patient-controlled postoperative analgesia with alfentanil. Adaptive, on-demand intravenous alfentanil or pethidine compared double-blind for postoperative pain.
A double-blind study comparing alfentanil and pethidine given intravenously by an adaptive, patient-controlled on-demand analgesic system is described. It was demonstrated that, despite its well-known rapid onset of effect, alfentanil took several hours to achieve good quality analgesia. ⋯ Alfentanil was associated with significantly less sedation during the postoperative period than pethidine, and was also associated with a significantly greater urine output during the 24-hour period of study. There was no evidence of tolerance or accumulation with either of the two drugs.