Croatian medical journal
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Croatian medical journal · Aug 2020
Axon morphology of rapid Golgi-stained pyramidal neurons in the prefrontal cortex in schizophrenia.
To analyze axon morphology on rapid Golgi impregnated pyramidal neurons in the dorsolateral prefrontal cortex in schizophrenia. ⋯ Axon rapid Golgi impregnation stops at the beginning of the myelin sheath. The increased axonal staining in the schizophrenia group could, therefore, be explained by reduced axon myelination. Such a decrease in axon myelination is in line with both the disconnection hypothesis and the two-hit model of schizophrenia as a neurodevelopmental disease. Our results support that the cortical circuitry disorganization in schizophrenia might be caused by functional alterations of two major classes of principal neurons due to altered oligodendrocyte development.
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Croatian medical journal · Aug 2020
The effect of COVID-19 lockdown on lifestyle and mood in Croatian general population: a cross-sectional study.
To investigate the effect of the coronavirus 2019 (COVID-19) lockdown on lifestyle behaviors and mood changes in the Croatian general population. ⋯ Public health authorities should promote the adoption of healthy lifestyles in order to reduce long-term negative effects of the lockdown.
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Croatian medical journal · Aug 2020
Safety and efficacy of nivolumab as a second line therapy in metastatic renal cell carcinoma: a retrospective chart review.
To assess diseases outcomes and tolerability of real-life second-line nivolumab in a series of metastatic renal cell carcinoma (mRCC) patients. ⋯ The present study indicates acceptable patient responses and tolerability of nivolumab in mRCC.
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Croatian medical journal · Aug 2020
Case ReportsSpontaneous full thickness macular hole development and closure in a patient with nucleus dislocation due to hypermature cataract: a case report.
Spontaneous posterior capsule rupture with lens-nucleus dislocation is a very rare entity, as is the development and spontaneous closure of a full thickness macular hole (FTMH) after vitrectomy. The occurrence of these two entities in one eye has not been previously described. A 79-year-old woman was referred because of the right eye intermittent pain and progressive visual loss. ⋯ A dislocated crystalline lens in a quiet eye with normal BCVA, which rapidly developed into intractable glaucoma and FTMH, is an unusual finding. The deterioration was followed by spontaneous IOP normalization and macular hole closure. Such unexpected disease course, suggesting a possible autoimmune reaction, has not yet been described.