Acta clinica Croatica
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Acta clinica Croatica · Nov 2023
PHARMACOVIGILANCE IN SERBIA: A TEN-YEAR PHARMACOEPIDEMIOLOGIC ANALYSIS.
Pharmacovigilance as a science and group of activities related to detection, collection, analysis, understanding and prevention of adverse drug reactions (ADRs) is an essential activity in the regulatory system of drugs of any country. Defining increased patient safety as the main purpose of ADR reporting, a well-designed national pharmacovigilance system achieves its ultimate goal, i.e., protection of public health. ⋯ Unlike the neighboring Croatia and Montenegro with similar pharmacovigilance systems, Serbia has only recently approached the WHO standard of 200 reports per million inhabitants despite a significant increase of 180 ADR reports per million inhabitants in 2019 (1251 in total). Considering this, our study aimed to provide a critical insight into the practice of pharmacovigilance in Serbia by pharmacoepidemiologic analysis of a ten-year period of ADR monitoring and reporting activities.
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Acta clinica Croatica · Nov 2023
THE EFFECT OF EDUCATION AND EMPLOYMENT ON SEXUAL ACTIVITY AFTER CHILDBIRTH.
The aim of the study was to explore the relationship between educational level, employment status and sexual activity after delivery. The study was conducted on 286 women with experience of vaginal delivery who completed the questionnaire about age, education, employment, and health status for themselves and partners. Time of the first intercourse and its frequency in the first year after childbirth was observed. ⋯ Most women had high education (n=170, 59.4%), 114 (39.9%) had secondary, and 2 (0.7%) had primary educational level. Although there were significant differences in the time of the first intercourse and maternal educational level (p=0.013872), partner's employment status (p=0.007403) and maternal age (p= 0.01107), as well as differences in the frequency of intercourse in the first year following delivery and partner's educational level (p=0.016929), multiple correlation coefficients indicated a very weak correlation. According to study results, the correlation of educational level, employment status and sexual activity after childbirth is weak.
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Acta clinica Croatica · Nov 2023
ASSOCIATION BETWEEN ALLERGIC REACTIONS AND LIP INFLAMMATORY LESIONS (CHEILITIS).
The purpose of this study was to examine the possible association between cheilitis and allergic reactions, and to use allergy skin tests to identify the allergens that induce allergic reactions in cheilitis patients (type I and type IV). We included 50 patients with recurrent cheilitis (reversible cheilitis) who were dermatologically examined and agreed to undergo allergy skin tests, i.e., patch test and prick test. Additionally, clinical pictures and patient mental stress levels were examined using the Perceived Stress Scale (PSS). ⋯ Also, low stress levels were recorded less frequently in patients with confirmed allergies than in non-allergic patients. The results indicated a higher incidence of cheilitis in the people prone to allergies (atopics) and confirmed an association between cheilitis and allergies. To our knowledge, this is the first study in patients with cheilitis, which simultaneously analyzed allergies, their clinical features and PSS in the same patients.
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Acta clinica Croatica · Nov 2023
ANALYSIS OF TIME, PLACE AND METHOD OF SUICIDE IN THE AREA OF BJELOVAR-BILOGORA COUNTY IN THE 1988-2017 PERIOD.
The aim of the study was to analyze changes in the number of suicides associated with seasonal variables, calendar month, time of day versus variable location and method of suicide. Data were obtained from the Analytical Police Department of Bjelovar-Bilogora County for the 1988-2017 period. The process of Croatian application process into the European Union, accompanied by economic and social changes, was a significant socioeconomic event, which divided the analyzed period into two parts. ⋯ In the case of time of day and location of the suicides, there was no significant difference when comparing results between the 1988-2004 and 2005-2017 periods; however, a statistically significant difference was confirmed when considering the month of suicide (February) and season (winter, borderline result for autumn). Statistically, the most significant changes were found in the methods of suicide. The two observed periods differed in the mean suicide rate.
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Acta clinica Croatica · Nov 2023
DOES THE PRESENCE OF CHRONIC LYMPHOCYTIC THYROIDITIS AFFECT DIAGNOSTIC VALUE OF FINE NEEDLE ASPIRATION BIOPSY IN BETHESDA CATEGORY III NODULES?
This study aimed to determine the relationship between the presence of Hashimoto's thyroiditis (HT) and malignancy rates with prognostic factors in thyroid nodules diagnosed as Bethesda category III, and to examine the effect of HT on diagnostic value of fine-needle aspiration biopsy (FNAB). Demographic information, preoperative examination, and final pathological evaluation of patients with Bethesda category III (AUS-FLUS) nodules who had been operated on in our department over the last 6 years were analyzed. Statistical analyses were performed using the Student's t-test, Mann-Whitney U test and χ2-test and logistic regression analysis using SPSS version 22 software. ⋯ Poor prognostic factors such as multifocality, number of metastatic lymph nodes (p=0.04), and extrathyroidal extension were more common in patients with cancer in the pathology specimen who were in the non-HT group. It cannot be said that HT decreases diagnostic value of FNAB in lesions diagnosed with AUS-FLUS. The lower incidence of poor prognostic factors in the HT group may be attributed to cytotoxic cell dominance in tumor immunity.