Canadian respiratory journal : journal of the Canadian Thoracic Society
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Randomized Controlled Trial
The effect of inhaled menthol on upper airway resistance in humans: a randomized controlled crossover study.
Menthol (l-menthol) is a naturally-occurring cold receptor agonist commonly used to provide symptomatic relief for upper airway congestion. Menthol can also reduce the sensation of dyspnea. It is unclear whether the physiological action of menthol in dyspnea reduction is through its cold receptor agonist effect or whether associated mechanical changes occur in the upper airway. ⋯ Inhalation of menthol does not alter upper airway resistance in awake human subjects.
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Randomized Controlled Trial Comparative Study
Wet laboratory versus computer simulation for learning endobronchial ultrasound: a randomized trial.
Linear endobronchial ultrasound with transbronchial needle aspiration (EBUS-TBNA) is a revolutionary bronchoscopic procedure that is challenging to learn. ⋯ Computer EBUS-TBNA simulation and wet lab simulation are effective methods of learning basic EBUS-TBNA skills and appeared to be complementary.
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Randomized Controlled Trial Multicenter Study
Impact of Candida species on clinical outcomes in patients with suspected ventilator-associated pneumonia.
The significance of Candida species in respiratory tract (RT) secretions in critically ill patients is unclear. ⋯ Patients with suspected VAP, in whom no bacterial pathogen was identified and in whom Candida species were isolated from RT cultures, exhibited a greater burden of illness compared with similar patients without Candida. Whether Candida species colonization of RT secretions is a marker of disease severity or actually contributes to poorer clinical outcomes remains unclear.
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Randomized Controlled Trial Comparative Study
Prophylactic positive end-expiratory pressure and postintubation hemodynamics: an interventional, randomized study.
To investigate the hemodynamic and outcome effects of implementing prophylactic positive end-expiratory pressure (PEEP) versus zero end-expiratory pressure (ZEEP) in patients during the postintubation period in the emergency setting. ⋯ In the present trial, there was no evidence that implementing a prophylactic PEEP of 5 cmH2O adversely affects short-term hemodynamics or outcome in medical intensive care patients during the postintubation period.
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Randomized Controlled Trial
Assessment and management of patients with chronic cough by Certified Respiratory Educators: a randomized controlled trial.
The value of other health care professionals is increasingly being recognized to compensate for the shortage of physicians in Canada. Chronic cough is one of the most common reasons for consultation with a respirologist. In the present study, a prospective, randomized, controlled study was undertaken to determine whether Certified Respiratory Educators (CREs) could manage screened patients with chronic cough as effectively as respirologists. ⋯ CREs can safely and effectively assess, as well as appropriately treat, screened patients with chronic cough with a resultant reduction in wait times.